Anticoagulant activity of partially purified coumarin(s) extracts of Sonchus oleraceus

Abstract

The present investigation was aimed to isolate and characterize coumarin from Sonchus oleraceus. By all the three standard tests presence of couamrin in the plants was confirmed. The same extract was used for anticoagulant assays. aPPT assay and PT assay were performed on citrated plasma of healthy volunteer donors with different concentration of coumarin extract. The coumarin extract prolonged/delayed the time taken for blood clotting in all the tested methods. The activity was increased with the concentration of extracts used. The coumarin extract can be used as anticoagulant and further in detail work is needed for the characterization of the active coumarin molecule.

Keywords: Sonchus oleraceus, coumarin, anticoagulant, aPPT, PT.