Influence of ozonotherapy on the functional status and medical aspects of quality of life in patients with bronchial asthma

Abstract

The objective of this study is the assessment of interrelations of the structurally-functional condition of cardio-pulmonary system with medical aspects of quality of life and effects of ozonotherapy in patients suffered from cor pulmonale secondary to bronchial asthma. This randomized, quasi-experimental interventional study was conducted on 55 participants. 22 patients suffered from corpulmonale secondary to bronchial asthma and 30 healthy persons (HP) were studied. Depending on methods of intervention, participants were divided into the 2 groups: 1^st group (12) and 2^nd group (10) received routine basic therapy (BТ) combined with ozonotherapy as intravenous introduction Ozonized saline, 1000 mg/L. In cor pulmonale patients secondary to bronchial asthma with Right Ventricular Enlargement is more expressed in the reduction of quality of life on a physical condition and satisfaction by the intervention, in CP patients secondary to BA with pulmonary hypertension on an emotional condition and occupational suitability that is necessary to note during the adequate treatment. Infringements of respiratory system and quality of life are positively correlate pulmonary ventilation ability, average of pulmonary arterial pressure condition and remodeling of the right ventricle of hearts; ozonotherapy on the combined with the routine standard therapy can improve the above stated pathogenicity interconnected infringements. It seems that combination of ozonotherapy along with routine modality can lead to improve pulmonary function of CP secondary to BА, reduction of preload of right heart as well as improvement of RV structure. Also application of this combined method of therapy can lead to efficacy of treatment and better quality of life and reduced the use of urgent healthcare in CP secondary to BА patient.

Keywords: Pulmonary rehabilitation, pulmonary hypertension, chronic obstructive pulmonary disease, pulmonary function test, combination therapy, complex therapy.