Periwinkle (Pachymelania aurita) consumption induces in vivo electrolyte disorders

Abstract

Effects of aqueous periwinkle extract on plasma electrolytes were investigated in 20 albino rats for 28 days. Here, we found significant increase in sodium concentration in group 2, administered with cooked periwinkle extract, group 2 with uncooked extract group 3 and group 4 with cooked and uncooked extract as compared with control group (P < 0.01). Potassium concentration was significantly decreased in groups 2 (P < 0.05), 3 and 4 (P < 0.01) compared to group 1 (P < 0.05). There was a significant increase in chloride ion in groups 2, 3 and 4 compared to group 1 (P < 0.05). An increase in bicarbonate in groups 3 and 4 as compared to groups 1 and 2 (P < 0.01). Also, calcium concentration was significantly higher in group 3 compared to groups 1 and 2 (P < 0.01). Plasma pH was increased in groups 2 and 4 compared to groups 1 and 3 (P < 0.05). Acute toxicity (LD₅₀) test showed higher mortality at an increased dosage (5000 mg/kg). Periwinkle extracts should, therefore, be consumed with caution due to its negative effects on electrolyte balance and plasma markers.

Keywords: Type 2 diabetes mellitus, quality of life, clinical factors.