Dynamics of the nitroergic system in experimental hypercholesterolemia

Abstract

Hypercholesterolemia and atherosclerosis remain the main cause of mortality in Central Asia. Our objective was to study the molecular mechanisms of endothelial dysfunction with changes in the nitroergic system in experimental hypercholesterolemia. The experiments were carried out on 28 Chinchilla rabbits with an average weight of 2.5-3.0kg. The action of drugs was studied in dynamics: the initial 3-month condition and after one month of drug administration. The results obtained were compared with those of the control and intact groups. The activity of the enzyme nitrate reductase in the blood serum on the 30th day of the introduction of exogenous cholesterol increases only 1.15 times, then on the 60^th and 90^th days of the introduction -1.3 and 1.76 times. In the dynamics of hypercholesterolemia and atherosclerosis in the blood serum, there are noticeable disturbances in the NO-ergic system.

Keywords: Hypercholesterolemia, atherosclerosis, nitrate reductase, endothelin, endothelial dysfunction, NO-ergic system.

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