Oxidative stress and endoplasmic reticulum stress induced hepatic steatosis

Abstract

The hepatic steatosis is strongly associated with obesity, hyperlipidemia, and type 2 diabetes mellitus. Experimental and clinical studies increasingly show that the oxidative stress and endoplasmic reticulum stress (ER stress) contribute in many ways to the pathogenesis of hepatic steatosis. Although there is a plethora of studies on ER stress and associated diseases, the core pathophysiological mechanism of ER stress-associated ROS has not yet been fully clarified. In this review, we will discuss the correlation of ER stress with oxidative stress and lipid disorders, and the understanding of ER stress and its cofactors in pathological processes may provide new perspective on disease development and control.

Keywords: Oxidative stress, endoplasmic reticulum stress, hepatic steatosis.