Genetic, environmental and dietary factors affecting the prognosis of allergic rhinitis

Abstract

The transporters associated with antigen presentation (TAP) genes polymorphism could play a role in the pathogenesis of allergic rhinitis. The aim of this study was to investigate the association of TAP genes polymorphism with allergic rhinitis in Egyptian population (by PCR and REFLP), investigate the effect of omega-3 capsules versus fish oil supplementation for treatment, study MCAM (by enzyme-linked immunosorbent assay) as a diagnostic and prognostic biomarker, study the incidence of allergy to textile dyes and the effect of replacement of synthetic by natural dyes on treatment. The results showed that the frequency of TC and AG genotypes were significantly higher in cases than controls, MCAM is a sensitive diagnostic and prognostic biomarker, omega-3 or better fish oil supplements and replacement of synthetic dyes by natural ones could improve allergic rhinitis patients.

Keywords: Allergic rhinitis, TAP1, TAP2 polymorphism, MCAM, omega-3, fish oil.