Toxic effects and DNA transformation

Abstract

In this paper, mutation point in the nucleotides transformations was studied. The major purine and pyrimidine bases were analyzed. Mutation are hereditary changes in genetic information, resulting from spontaneous or xenobiotic induced DNA damage. Point mutation and frame shift mutations were considered. Phosphorylation is the most important in the synthesis of purine and pyrimidine nucleosides and DNA damage. This paper considers impact of toxic effects to phosphorylation reactions modifications.

Keywords: Mutation, genes, DNA bases, chromosomes, mutation mechanism, metabolism.